This course will provide an overview of the current major genome engineering platforms and cover CRISPR genome editing technology in depth. The first part of the course will focus on the general principles of genome editing technology including design, choice of format, delivery, efficiency, specificity, clonal isolation, genotyping, and validation. The second part of the [....]
Background Computational techniques have become essential in guiding and complementing experimental efforts to gain insight into the structure and function of proteins. In particular, molecular modeling and dynamics simulations play key roles in modern studies of molecular recognition, drug design, functional mechanisms, conformational changes, and protein evolution. Therefore, developing fundamental understanding of these techniques will [....]
This five-day online workshop will utilize a combination of lectures and remote Q&A lab sessions in a “boot camp”-like approach for cell-biologists who seek to learn imaging techniques used extensively in biomedical research. Lecture Topics to Include Introduction to Fluorescence Microscopy Immunofluorescence (with workflows) RNAScope (with workflows) Cell Transfection for Fixed and Live Cell Imaging [....]
Online review course for intended both for physicians who are preparing for the Endocrinology subspecialty board examination and for physicians certified in Endocrinology who wish to remain abreast of recent advances in the field activity. This fully online review course will also cover the development of efficient and cost-effective approaches to the clinical, laboratory, and [....]
In order for a drug to get approved by the FDA for market in the USA, the sponsor must ultimately demonstrate the drug has: 1) a predictable exposure profile with dose, 2) a good safety profile, and 3) is effective at safe doses. Therefore, the pharmacology of a drug is essentially being reviewed by the [....]
This course will address the basic principles of epigenetics, the role of epigenetic mechanisms in normal development and human disease, and the development of epigenetically-effective drugs. The objective of the program is to provide a solid foundation of information enabling participants to design experiments when returning to their own research lab. Furthermore, to provide a [....]
