The Evolving Hunt for an HIV Cure, and How Gene Therapy is Paving the Way

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Today, a host of life sciences companies are utilizing gene therapy as a tool to find a cure for HIV. When discussing an HIV cure, there are two different possible targets: a “functional cure” where HIV is not eradicated but rather totally controlled without further ART treatment and a “sterilizing cure” that eliminates HIV completely from the body. 

American Gene Technologies says clinical trial shows increases in immunity against HIV

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ROCKVILLE, Md. (7News) — There’s more good news in the fight to cure HIV.
American Gene Technologies says its clinical trial has resulted in more patients with substantial increases in virus-specific T-cells with immunity against HIV.
Progress in HIV cure: AGT hopes to have a ‘functionally cured patient by next summer’
“Now the question will be the very final step when we withdraw antiretroviral therapy, will it behave as we expect which is to take over viral suppression and these patients will not need to go back on their antiretroviral therapy again,” said CEO Jeff Galvin.
He says that process would start by the end of March at the earliest and he hopes to find out how successful it is by June.

Mission, Purpose, and Reducing Human Suffering Propel American Gene Technologies Forward

Collage of photos of AGT employees, scientists in the lab, and the AGT office building
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Rockville, Maryland’s American Gene Technologies (AGT) is on a mission to cure HIV. And they just achieved another important milestone in that potentially groundbreaking journey.

In early November 2021, the company announced that the third patient in its first-in-human study for AGT103-T, a cell therapy for HIV, had been dosed with no serious adverse events. This latest milestone achievement moves the company and its team another step closer to curing HIV and making history.

With a Chance to Cure HIV, American Gene Technologies Offers Employees a Front Seat to History

Hand holding blood test vial marked as HIV negative
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There is a growing movement of professionals seeking jobs with a purpose. The mission-driven culture of a company is a powerful attraction for those value-driven prospective applicants. Curing HIV is one of the bolder missions to be found in the I-270 technology corridor. With its bold mission to develop a cure for HIV, American Gene Technologies Business Development head Norman Rogers said that it’s an “attractive position for people who want a front seat to history.”

Dr. Anthony Fauci & AGT’s Jeff Galvin Join ‘I AM BIO’ to Discuss Future of HIV Treatments

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EPISODE SUMMARY
For more than a year now, COVID has been society’s focus—and rightly so. But today we turn our attention to another virus—HIV. After 40 years, there is still no cure or a vaccine for the disease. In this episode, we hear from Dr. Anthony Fauci and CEO of innovative company American Gene Technologies, Jeff Galvin, about the past, present, and future of HIV treatments and medications. Is there a cure on the horizon?
Guests:
Jeffrey Galvin, American Gene Technologies
Anthony Fauci, National Institute of Allergy and Infectious Diseases
EPISODE NOTES
For more than a year now, COVID has been society’s focus—and rightly so. But today we turn our attention to another virus—HIV. After 40 years, there is still no cure or a vaccine for the disease. In this episode, we hear from Dr. Anthony Fauci and CEO of innovative company American Gene Technologies, Jeff Galvin, about the past, present, and future of HIV treatments and medications. Is there a cure on the horizon?  

AGT’s HIV Cure Cell Therapy Clears First Safety Hurdle with DSMB Nod

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American Gene Technologies’ goal to develop a cure for HIV moved one step closer to reality. After infusing the first patient with its cell therapy candidate AGT103-T, the company announced the Data and Safety Monitoring Board unanimously supported the continuation of the clinical study without modification.

American Gene Technologies HIV Cure Program Releases Initial Clinical Trial Data

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American Gene Technologies (AGT) announced today that the Data and Safety Monitoring Board (DSMB) voted unanimously to continue AGT’s HIV cure program without modification, after safety analysis of the participant’s data revealed no adverse effects from the treatment. AGT’s Phase 1 trial of AGT103-T, a new cell and gene therapy for HIV disease, is designed to induce durable viral suppression by delivering therapeutic genes to the recipient’s immune cells. The cells are collected by leukapheresis, modified outside the body, then re-infused. Once infused, the cells are expected to durably suppress the virus at undetectable levels without the need for antiretroviral treatment.

First Participant Infused with Potential HIV Cure Enters Phase 1 Clinical Trials via American Gene Technologies AGT103-T

HIV Cure
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One year after receiving the green light from the FDA to initiate a Phase I study of an HIV gene therapy, American Gene Technologies (AGT) has infused the first patient. AGT103-T is designed as a cure for the disease that has wreaked havoc across the globe since the 1980s.

LGBT+ investment firm Gaingels joins American Gene Technologies’ mission to cure HIV, and other serious human diseases

LGBT+ investment firm Gaingels joins American Gene Technologies
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American Gene Technologies (AGT), an emerging gene and cell therapy company, announced today that Gaingels, a leading venture investment syndicate in service of the LGBT+ community and its allies, made an investment in AGT to support the Phase 1 clinical trial of an HIV cure. The Phase 1 human trial is investigating the safety of AGT103-T, a single dose, autologous cell therapy intended to cure the disease. This investment places Gaingels alongside private investors who believe deeply in AGT’s mission, rapid drug development platform, and gene and cell therapy programs for HIV, cancer, and PKU.